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M94A0714.TXT
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1994-10-21
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Document 0714
DOCN M94A0714
TI HIV related dementia.
DT 9412
AU Strain J
SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:23 (abstract no.
FPI-4). Unique Identifier : AIDSLINE ASHM5/94348941
AB This paper will address the prevalence, the etiology, and the treatment
of the organic mental disorders that accompany HIV infection, with
special attention to the dementias. Late-stage HIV infection is
frequently associated with a syndrome of progressive dementia,
presumably etiologically related to the virus activity in the brain,
although it may occur at any stage of the disease, even as the
presenting symptom. Navia and Price described this clinical stage as
AIDS dementia complex (ADC). Macrophages, microglia and neuronal cells
have been found to be affected by the virus in autopsy specimens.
Studies describe that the prevalence of HIV dementia among AIDS patients
ranges from 50% to 70%. Early diagnosis is complicated by the relative
nonspecificity of the most common symptoms: short term memory
dysfunction, mild confusion, psychomotor slowing, and headache, which
can be confused with depression or reactions to the illness. Advanced
dementia in HIV patients is characterised by severe memory loss,
incoordination, tremor, hyper-reflexion, disturbances of gait, paranoid
states, and seizures. Chemotherapeutic and psychotherapeutic management
of these organic states will be discussed.
DE AIDS Dementia Complex/*DIAGNOSIS/PATHOLOGY/THERAPY Brain/PATHOLOGY
Combined Modality Therapy Human Macrophages/PATHOLOGY
Microglia/PATHOLOGY Neurologic Examination Neurons/PATHOLOGY
Neuropsychological Tests MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).